| Hoe gevaarlik is 'heelende middels' [boodskap #37555] |
Mon, 04 December 2000 00:00 |
Ernst v Biljon
Boodskappe: 257
Geregistreer: March 1999
Karma: 0
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Na aanleiding van Sue se vraag oor DDT, het dit my laat dink aan hoe ons
die liggaam verniel. Ons gebruik middele wat die liggaam afbreek en die
dood vervroeg. Daar is byvoorbeeld rook en lood misbruik (gevind in
petrol).
Maar, wie het gedink dat medisyne gevaarlik mag wees. Medisyne is moes
goed vir die mens? Hier volg 'n medisyne beskrywing (natuurlik
verkrygbaar) maar, die wetenskap het 'n manier gevind om dit kunsmatig
te maak. Dit word gebruik vir die behandeling van Gout. Die effek is 'n
natuurlike vorm van chemoterapie wat selfs witbloedselle aanval. Wit
bloed selle word gebruik om die liggaam te beskerm. Lees verder:
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Colchicine, a water-soluble alkaloid found in the autumn crocus, blocks
or suppresses cell division by inhibiting mitosis, the division of a
cell's nucleus. Specifically, it inhibits the development of spindles as
the nuclei are dividing. Normally, the cell would use its spindle fibers
to line up its chromosomes, make a copy of them, and divide into two new
cells with each daughter cell having a single set of chromosomes. With
colchicine present, the spindle fibers don't form, and so the cell can't
move its chromosomes around. The cell may end up copying some or all of
the chromosomes anyway, but can't parcel them out into new cells, and so
it never divides.
Because cancer cells divide much more rapidly than normal cells, cancers
are more susceptible to being poisoned by mitotic inhibitors such as
colchicine, paclitaxel, and the Vinca alkaloids.
However, colchicine has proven to have a fairly narrow range of
effectiveness as a chemotherapy agent, so its only FDA-approved use is
to treat gout (it is one of the active ingredients of ColBenemid,
anti-gout tablets marketed by Merck & Co.), though it is also
occasionally used in veterinary medicine to treat cancers in some
animals. It is also used as an antimitotic agent in cancer research
involving cell cultures.
Gout is an illness caused by faulty uric acid metabolism in which excess
uric acid is turned into crystals of sodium urate, which are then
deposited in the joints (most often in the big toe), causing
inflammation and pain. Researchers aren't sure exactly how colchicine
works against gout, but it does seem to reduce the frequency of severe
attacks and relieves residual pain.
As far as side effects go, colchicine can cause a temporary reduction in
the number of leukocytes (white blood cells) in the bloodstream;
afterward, the leukocyte count can rebound to abnormally high levels.
Colchicine also causes teratogenic birth defects in lab animals, and so
pregnant women with gout should not use colchicine-containing drugs.
Colchicine poisoning resembles arsenic poisoning; the symptoms (which,
because it is a mitotic poison, occur 2 to 5 hours after the toxic dose
has been ingested) include burning in the mouth and throat, diarrhea,
stomach pain, vomiting, and kidney failure. Death from respiratory
failure often follows. A specific antidote doesn't exist, so treatment
typically involves giving the victim activated charcoal or pumping the
stomach.
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